![]() ![]() Studies can be made of sub-regions of tissues, mammalian cells, and bacteria. This capability for multiple isotope imaging with high spatial resolution provides a novel new approach to the study of biological materials. Lastly, we present a perspective on the future of this technology and where we think it will have the greatest impact in near = ) can be scanned across the sample to produce quantitative secondary ion images. ![]() Additionally, we provide an open-source method for data representation that allows simultaneous visualization of secondary electron and ion information within a single image. We describe the major experimental factors that should be considered prior to NanoSIMS analysis and then provide information on best practices for data analysis and image generation, which includes an in-depth discussion of appropriate colormaps. Specifically, we offer an overview of SIMS and development of the NanoSIMS. Here, we provide a review of this technology, sample preparation and analysis considerations, examples of recent biological studies, data analysis, and current outlooks. Of these, high lateral resolution methodologies using the NanoSIMS 50/50L have been especially powerful within many biological fields over the past decade. Secondary ion mass spectrometry (SIMS) has become an increasingly utilized tool in biologically-relevant studies. ![]()
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